Ramipril is a highly lipophilic, long
acting ACE inhibitor. The drug is used for treating blood pressure and
congestive heart failure. It effectively reduces both supine and standing
blood pressure without significant alteration in the pulse rate.
Brand Name: Altace, Tritace
Iupac Name:(1S,5S,7S)-8-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-8-azabicyclo[3.3.0]octane-7-carboxylic
acid
Working
The drug acts by lowering the production of Angiotensin II, therefore
relaxing arterial muscles while at the same time enlarging the arteries. The
process allows the heart to pump blood easier, and increasing the blood flow
due to more blood being pumped into and through bigger passageways.
Dosage
Hypertension: 2.5 mg/day, Max: 10mg /day.
Cardiac Failure: 1.25mg/day, increased to 2.5 mg once daily,
Max:10mg/day
Contra- Indications: Hypersensitivity, bilateral renal artery
stenosis, pregnancy, lactation.
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Hypotension
- Renal impairment
- Cough
- Hyperkalemia
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.