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Omeprazole is widely used proton pump inhibitor for treating various types of gastrointestinal ulcers, dyspepsia gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. The drug is one of the most widely prescribed all over the globe and is also available over the counter in some countries.
It is a gastric proton pump inhibitor. Omeprazole is a substituted benzimidazole derivative acting on the final step of acid production & therefore controls intragastric acidity irrespective of stimulus. It markedly inhibits basal and stimulated gastric acid secretion. Thus it is antisecretory drug which is very effective for rapidly healing peptic ulcers & erosive oesophagitis & for reducing gastric acid hyper-secretion in patients with Zollinger-Ellison syndrome.
The drug acts by relaxing blood vessels so that blood passes through them more easily. This further helps to lower blood pressure.
Gastric ulcer: 20 mg once daily for 8 weeks in sever cases increase to0 40 mg once daily
Duodenal ulcer: 20 mg once daily for 4 weeks.
Zollinger Ellison Syndrome: 60 mg once daily.
Maintenance therapy: 20 0120 mg adjusted to response.
The drug has certain side effects, that can affect individuals in different ways. The following are some of the side effects, that are often associated with the drug:
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