Omeprazole is widely used proton
pump inhibitor for treating various types of gastrointestinal
ulcers, dyspepsia gastroesophageal reflux disease (GORD/GERD) and
Zollinger-Ellison syndrome. The drug is one of the most widely
prescribed all over the globe and is also available over the counter
in some countries.
It is a gastric proton pump inhibitor. Omeprazole is a substituted
benzimidazole derivative acting on the final step of acid production
& therefore controls intragastric acidity irrespective of
stimulus. It markedly inhibits basal and stimulated gastric acid
secretion. Thus it is antisecretory drug which is very effective for
rapidly healing peptic ulcers & erosive oesophagitis & for
reducing gastric acid hyper-secretion in patients with
Zollinger-Ellison syndrome.
Brand Name: Prilosec, losec
Iupac Name:
5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-3H-benzimidazole
Working
The drug acts by relaxing blood vessels so that blood passes
through them more easily. This further helps to lower blood
pressure.
Dosage
Gastric ulcer: 20 mg once daily for 8 weeks in sever cases
increase to0 40 mg once daily
Duodenal ulcer: 20 mg once daily for 4 weeks.
Zollinger Ellison Syndrome: 60 mg once daily.
Maintenance therapy: 20 0120 mg adjusted to response.
Contra- Indications: Hypersensitivity, neonates
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Skin rash
- Nausea
- Headache
- Constipation
- Flatulence
The drug's safety has not been established for use by pregnant
and lactating women
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.
