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Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels. It is an analgesic and antipyretic in action, apart from its anti inflammatory action. Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group. It is absorbed rapidly and completely after oral administration.
Original nimesulide is manufactured by Helsinn Healthcare and distributed world-wide through a network of selected international partners. The most popular brands are:
For Oral Use in Humans: sulide, nimalox, nilsid (Egypt), mesulid, Drexel, Donulide, Aulin, Ainex, Heugan, Mesulid, Minapon, NeRelid, Edrigyl, Enetra, Eskaflam, Nexen, Nidolon, Nilden (Mexico), Nimulid, Nimutab, Nise, Nisulid, Nimed, Nimedex, Nimesil, Nodard Plus, Nicip (India), Novolid, Pain Lock(VIP Pharma India ), Relmex (Ecuador), Scaflam, Scaflan, Sulidin® (Turkey), Modact-IR (Pakistan).
There are also many generic and copy-products by the brand names of Nidol, Nimalox, Nimesil, Nimotas, Nimulid, Coxtral, Lusemin, Medicox, Nise, Nizer, Sorini, Ventor, Vionim, Neolide, Willgo among others).
The main purpose of using nimesulide are:
It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation
Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.
The drug has certain side effects, that can affect individuals in different ways. The following are some of the side effects, that are often associated with the drug:
It is to be noted that nimesulide has been drawn aside from the pharmaceitical market because of its hepatic effects (risk of hepatatoxicity) on patients. The drug was already banned in over 170 countries worldwide including US, Britain, Canada, Sweden, Denmark, Japan, Australia and New Zealand. Nimesulide causes serious side effects including liver toxicity. In India this drug was banned beginning this year 2011.
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