Nimesulide is a popular NSAID
and available in various forms including tablets, suppositories,
water-soluble powders, and topical gels.
It is an analgesic and antipyretic in action, apart from its anti
inflammatory action. Unlike, other NSAIDs, the chemical structure of
nimesulide does not contain a carboxylic group but a sulfonanilide
moiety as the acidic group. It is absorbed rapidly and completely
after oral administration.
Brand Name: Ainex, Aulin, Donulide, Edrigyl, Eskaflam,
Heugan, Lusemin
Working
It acts by inhibiting the release of tumour necrosis factor-alpha,
acts as a competitive inhibitor of histamine release and reduces
superoxide anion formation
Dosage
Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.
Contra- Indications: Hypersensitivity, active peptic ulcer
disease, hepatic impairment
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Diarrhoea
- Vomiting
- Skin rash
- Pruritis
- Dizziness
- Headache
Women should use the drug with caution during lactation and it
is contraindicated during pregnancy.
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.
