Lovastatin is a drug, belonging to the class of 'statins', used for
lowering cholesterol in patients having hypercholesterolemia. It also helps
to prevent cardiovascular disease. The drug is absorbed from GIT. It
undergoes extensive first pass metabolism in liver which is the primary site
of action.
It is highly bound to plasma protein. Absorption is reduced by
approximately 30% when administered on an empty somach rather than with
food. Lovastatin is eliminated primarily through fecal route which is 83% of
orally administered dose. 10% of the drug is eliminated by renal route.
Brand Name: Mevacor, Altocor, Altoprev
Iupac Name: [8-[2-(4-hydroxy-6-oxo-oxan-2-yl)ethyl]
-3,7-dimethyl-1,2,3,7,8,8a- hexahydronaphthalen- 1-yl] 2-methylbutanoate
Working
The drug works by blocking the body's ability to make cholesterol. It may
help reducing or lowering blood cholesterol in patients who are at risk of
getting heart disease or a stroke.
Dosage
10 to 80 mg per day in single or divided doses
Contra- Indications: Hypersensitivity, active liver disease or
unexplained persistent elevations of serum transaminases, pregnancy and
nursing.
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Flatulence
- Constipation
- Nausea
- Abdominal Pain
- Cramps
- Dyspepsia
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.