Losartan Potassium is an angiostein
II receptor (type AT1)antagonist. Losartan and its principle active
metabolite block the vasoconstrictor and aldosterone secreting effects of
angiostein II by selectively blocking the binding of angiostein II to AT1.
The drug is used for treating High blood pressure and preventing
progression of kidney diseases in patients suffering from type 2 diabetes.
Brand Name: Cozaar
Working
The drug acts by preventing the action of a hormone called angiotensin II
in the human body. Angiotensin II generally acts on special receptors in the
body, with two major results. One, it narrows the peripheral blood vessels ,
and two, it stimulates the production of hormone aldosterone, another
hormone in the body. Aldosterone hormone, causes salt and water to be
retained by the kidneys, there by increasing the volume of fluid in the
blood vessels. Losartan blocks the receptors that angiotensin II acts on,
and so prevents its actions.
Dosage
25-100 mg once or twice daily: starting and maintenance dose: 50 mg once a
day. In volume depleted patients: 25 mg once daily.
Contra- Indications: Hypersensitivity, pregnancy. Lactating mothers
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Diarrhoea
- Dyspepsia
- Myalgia
- Oedema
- Dizziness
- Headache
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
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