Losartan Potassium is an angiotensin II receptor (type AT1)antagonist. It
is a well known
prescription
drug, an oral medication that is recommended to treat high blood
pressure or hypertension and also preventing progression of kidney diseases
in patients suffering from type 2 diabetes. This is the first angiotensin II
receptor antagonist to be marketed by Abbott under the trade name LOT. This
is available in generic form. It may be used alone or in combination with
other drugs.
GENERIC NAME
Losartan
BRAND NAME
Cozaar
Uses of Losartan
- Losartan is used in the treatment of hypertension.
- The nedicine can also be used in treating left ventricular
hypertrophy (increase in muscle) and diabetic nephropathy (kidney
disease).
- Cazaar helps in reducing the risk of stroke in patients with
hypertension.
- Studies have shown that in patients receiving losartan, there is
reduced risk of combined cardiovascular death, stroke, and AMI compared
with other other
anti-hypertension
drugs.
How does Cozaar Losartan Works?
Losartan and its principle active
metabolite block the vasoconstrictor and aldosterone secreting effects of
angiostein II. This is done by selectively blocking the binding of
angiostein II to AT1. The drug acts by preventing the action of a hormone
called angiotensin II in the human body. Angiotensin II generally acts on
special receptors in the body, with two major results. One, it narrows the
peripheral blood vessels , and two, it stimulates the production of hormone
aldosterone, another hormone in the body. Aldosterone hormone, causes salt
and water to be retained by the kidneys, which increase the volume of fluid
in the blood vessels. Losartan blocks the receptors that angiotensin II acts
on, and so prevents its actions.
Losartan Dosage
25-100 mg once or twice daily: starting and
maintenance dose: 50 mg once a day. In volume depleted patients: 25 mg once
daily. As Losartan comes as a tablet, it is taken by mouth and can be taken
once or twice a day with or without food.
Contra- Indications
Do NOT use Losartan if:
- you are allergic to any ingredient in Losartan
- you are in your second or third trimester of pregnancy
- the patient is a child with severe kidney problems
Side Effects of Cozaar Losartan
The drug has certain side effects,
that can affect individuals in different ways. The following are some of the
side effects, that are often associated with the drug:
- Diarrhoea
- Heartburm
- Muscle cramps or weakness
- Dizziness
- Headache
Some side effects may be serious which require immediate medical attention
like swelling of the face, throat, lips, eyes, tongue, hands, feet, ankles,
or lower legs, hoarseness, difficulty in breathing or swallowing and chest
pain.
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Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.