Lisinopril is a popular drug, used
alone for treating high blood pressure or hypertension. The drug is also
used in combination with other medicines for treating heart failure. The
drug belongs to the class of angiotensin-converting enzyme (ACE) inhibitors.
Brand Name: Zestril, Prinivil, Lisodur
Iupac Name: 1-[6-amino-2- (1-carboxy-3-phenyl-propyl)
amino-hexanoyl]pyrrolidine- 2-carboxylic acid dihydrate
Working
Inhibition of ACE by lisinopril reduces the plasma angiostein Ii levels
which lead to vasodilation and reduction of aldosterone secretion thus
lowering the blood pressure. The drug acts by reducing certain chemicals,
responsible for tightening the blood vessels. This leads to smooth flow of
blood
Dosage
Hypertension: Initially 10 mg once daily
Maintenance dose: 20-40 mg /day. Max 80 mg once daily.
Contra- Indications: Hypersensitivity, aortic stenosis, outflow
obstruction, pregnancy, children and nursing mothers
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Headache
- Dizziness
- Cough
- Diarrhoea
- Hypotension
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
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