Lisinopril is a popular drug,
used alone for treating high blood pressure or hypertension. The
drug is also used in combination with other medicines for treating
heart failure. The drug belongs to the class of
angiotensin-converting enzyme (ACE) inhibitors.
Brand Name: Zestril, Prinivil, Lisodur
Iupac Name: 1-[6-amino-2- (1-carboxy-3-phenyl-propyl)
amino-hexanoyl]pyrrolidine- 2-carboxylic acid dihydrate
Working
Inhibition of ACE by lisinopril reduces the plasma angiostein Ii
levels which lead to vasodilation and reduction of aldosterone
secretion thus lowering the blood pressure. The drug acts by
reducing certain chemicals, responsible for tightening the blood
vessels. This leads to smooth flow of blood
Dosage
Hypertension: Initially 10 mg once daily
Maintenance dose: 20-40 mg /day. Max 80 mg once daily.
Contra- Indications: Hypersensitivity, aortic stenosis,
outflow obstruction, pregnancy, children and nursing mothers
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Headache
- Dizziness
- Cough
- Diarrhoea
- Hypotension
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.
