Levocetrizine or levocetirizine is a selective, long acting peripheral H1
receptor antagonist antihistamine. The increased polarity of the drug may
decrease distribution of the drug into the CNS, resulting in reduced
potential for adverse CNS effects. Tolerance does not occur. As it does not
readily cross the blood brain barrier, it does not cause sedation or
interfere with mental alertness or memory function.
The drug is highly effective and well-tolerated anti-histamine, introduced
for treating symptoms associated with seasonal allergic rhinitis, perennial
allergic rhinitis and chronic idiopathic urticaria.
Levocetrizine, a potent single isomer of cetrizine, binds twice as strongly
to histamine H1 receptors in vitro and also has a highly consistent and
predictable anti-histamine action.
Brand Name: Xusal, Xyzal
Iupac Name:
Desloratidine2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]
piperazin-1-yl]ethoxy]acetic acid
Dosage
Adults & children above 6 years: 5mg single intake orally
Children below 6 years: No adjusted dose
Elderly: Adjust dose on the basis of renal function
Contra- Indications: In severe renal impairment
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Headache
- Somnolence
- Dry mouth
- Mild Drowsiness
Use the drug with caution during pregnancy and lactation, as the drug may
pass into the breast milk.
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.