Glipizide is an oral blood-glucose-lowering drug of the sulfonylurea class.
It is used for treating patients with type 2 diabetes. The class of drugs in
which it belongs includes glyburide (Micronase, Diabeta), glimepiride
(Amaryl), tolbutamide (Orinase) and tolazamide (Tolinase).
GENERIC NAME
Glipizide
BRAND NAME
Glucotrol
Uses of Glipizide
Glipizide is a second generation sulfonyl ureas,
having a similar pharmacological profile, as that of Glibenclamide or
glicazide. The drug helps to control the blood sugar levels in the body. It
is used for treating noninsulin-dependent (Type II) diabetes mellitus
(NIDDM).
Working of Glipizide
The drug increases the amount of insulin in
the blood. It helps the human body to use insulin more efficiently. The drug
is available in tablet form. This drug is often combined with the intake of
proper diet and exercise. Patients with type 2 diabetes have high glucose
(sugar) levels in their blood and the pancreas is not able to produce the
increased amounts of insulin that are needed in the body. Glipizide reduces
blood glucose by stimulating the pancreas to produce more insulin. Glipizide
is not a cure for diabetes.
Dosage
2.5 -5 mg daily ½ hour before meals. Gradually
increase by 2.5-5 mg at weekly intervals to max 20 mg daily. The medicine
comes as tablets and extended-release (long-acting) tablets. The regular
tablet is usually taken 1 or more times a day. The extended-release tablet
is usually taken once a day with breakfast.
Contra- Indications: Juvenile diabetes mellitus. Pregnancy, stress.
Renal or hepatic dysfunction. Impaired adrenocortical function ketoacidosis.
Diabetic pre- coma and coma.
Side Effects of Glipizide
The drug has certain side effects, that
can affect individuals in different ways. The following are some of the side
effects, that are often associated with the drug:
- Nausea
- Uriticaria
- Thrombocytopenia
- Vomiting
- Diarrhoea
- Drowsiness
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Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.