Glibenclamide is a popular
anti-diabetic drug, belonging to class of sulfonylureas. The drug is widely
used for treating type II diabetes.
Single dose provokes a brisk release of insulin from pancreas. It acts on
beta cell membrane leading to enhanced calcium flux across it, hence the
degeneration.
Brand Name: Diabeta, Micronase, Glynase, Euglucon
Iupac Name: 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)
phenyl]ethyl]-2-methoxy-benzamide
Dosage
Initially 2.5 mg daily as a single dose at breakfast, increasing gradually
by another 2-5 mg. Maximum 15 mg daily.
Contra- Indications: Insulin dependent diabetes Mellitus. Diabetic
coma, severe metabolic decompensation, severe renal impairment,
hypersensitivity, pregnancy
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Nausea
- Vomiting
- Anorexia
- Pruritus
- Urticaria
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
Injection
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