Glibenclamide is a popular
anti-diabetic drug, belonging to class of sulfonylureas. The drug is
widely used for treating type II diabetes.
Single dose provokes a brisk release of insulin from pancreas. It
acts on beta cell membrane leading to enhanced calcium flux across
it, hence the degeneration.
Brand Name: Diabeta, Micronase, Glynase, Euglucon
Iupac Name: 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)
phenyl]ethyl]-2-methoxy-benzamide
Dosage
Initially 2.5 mg daily as a single dose at breakfast, increasing
gradually by another 2-5 mg. Maximum 15 mg daily.
Contra- Indications: Insulin dependent diabetes Mellitus.
Diabetic coma, severe metabolic decompensation, severe renal
impairment, hypersensitivity, pregnancy
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Nausea
- Vomiting
- Anorexia
- Pruritus
- Urticaria
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.
