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Glibenclamide


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Glibenclamide is a popular anti-diabetic drug, belonging to class of sulfonylureas. The drug is widely used for treating type II diabetes.

Brand Names of Glibenclamide

Diabeta, Micronase, Glynase, Euglucon

Uses of Glibenclamide

In every human body, there is a hormone called insulin produced by the pancreas and helps in controlling sugar levels in the blood. In type-II diabetic patients, insulin is produced in less qualntity or the body is inefficient to produce insulin. In suc a case, the blood sugar levels can become too high. The Glibenclamide medicine is recommended by most doctors for treating people with type 2 diabetes . Glibenclamide is a first line option for treating patients with non-insulin dependent diabetes, patients who are not overweight, or who cannot take metformin. It is used when diet and exercise have failed to control blood sugar levels. This drug can also be used in combination with other anti-diabetic medicines like as metformin under the trade names Glucovance and Glibomet, to provide an effective control of blood sugar.

How does Glibenclamide Diabeta Works?

The drug works mainly by stimulating the beta cells in the pancreas that produce insulin. Glibenclamide causes the beta cells to produce more insulin, which in turn helps to decrease the amount of sugar in the blood of people with type 2 diabetes. Single dose provokes a brisk release of insulin from pancreas. It acts on beta cell membrane leading to enhanced calcium flux across it, hence the degeneration.

Dosage of Glibenclamide Tablets

Glibenclamide tablets should normally be taken with, or immediately after, breakfast or the first main meal. Initially 2.5 mg daily as a single dose at breakfast, increasing gradually by another 2-5 mg. Maximum 15 mg daily.

Side Effects of Glibenclamide

The drug has certain side effects, that can affect individuals in different ways. The following are some of the common side effects, that are often associated with the drug
  • Blurred Vision
  • Constipation
  • Nausea
  • Vomiting
  • Anorexia
  • Pruritus
  • Urticaria
  • Sweating, paleness, headache

Glibenclamide not to be used in

  • Type 1 (insulin dependent) diabetes
  • Diabetic keto-acidosis
  • Diabetic coma or precoma
  • Severely decreased liver, kidney function
  • Pregnant women
  • Breastfeeding
  • Hereditary blood disorders called porphyrias

Disclaimer: The above information is for general understanding of the visitor. Please consult a registered medical practitioner before taking the aforesaid medicine.
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