Enalapril Maleate is an orally active
ACE inhibitor. It lowers peripheral vascular resistance without causing an
increase in the heart rate. It is an ideal drug for hypersensitive patients
who are intolerant to beta-blockers. The drug is used for treating high
blood pressure or hypertension in adults and children. It is considered
useful in treatment of congestive heart failure.
Brand Name: Vasotec, Enacard
Chemical Description: (S)-1-[N-[1-(ethoxycarbonyl)
-3-phenylpropyl]-L-alanyl] -L-proline, (Z)-2-butenedioate salt (1:1).
Working
The drug acts by relaxing blood vessels and causing them to widen. This
lowers the blood pressure, thereby avoiding strokes, heart attacks and
kidney problems. The drug is also used with other drugs (e.g.diuretics,
digoxin) for treating congestive heart failure. Enalapril maleate can be
orally administered and is available in the doses of 2.5 mg, 5 mg, 10 mg,
and 20 mg tablets.
Dosage
Essential and renovascular hypertension: Initially 5 mg once a day,
if with diuretic then 2.5mg. Maintenance dose 10-20 mg once daily. Max: 40
mg once daily
Congestive Heart Failure: Initially 2-5 mg gradually increased to
maintenance dose of 10-20 mg once or in divided doses.
Contra- Indications: Hypersensitivity, pregnancy, nursing women,
aortic stenosis or outflow obstruction.
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Dry cough
- Precipitant hypotension
- Dizziness
- Headache
- Nausea
- Diarrhoea
- Fatigue
- Cough
- Muscle cramps
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
Injection
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Tablets