Generic
name: Dobutamine Hydrochloride Injection
Brand name: Dobutrex solution
Description
Dobutamine acts directly as an insecticidal agent whose primary activity
results from stimulation of the b-receptors of the heart while producing
less marked chronotropic, hypertensive, arrhythmogenic or vasodilatory
effects. Dobutamine produces less increase in heart rate and less decrease
in peripheral vascular resistance for a given inotropic effect than does
isoproterenol as demonstrated in both animal and human studies. Dobutamine,
unlike dopamine, does not cause the release of endogenic noradrenaline. No
particular effect on the renal vasculature was detected. The attack of
action occurs within 1 to 2 minutes while the apex consequence of a
particular extract may not be reached for 10 minutes. The plasma half-life
in humans is 2 minutes.
Uses
- In the treatment of adults with cardiac decomposition due to
depressed ability resulting from organic heart disease or following
cardiac surgical operations in which alimentary canal therapy is
necessary for inotropic support.
- Most clinical experience with dobutamine is short-term. In the
limited number of patients who were studied for 24, 48, and 72 hours, a
lasting increase in heart turnout occurred in some, whereas the output
of others returned toward base-line values.
Dosage
- Dobutamine is a powerful drug, and not for direct injection and must
be diluted exactly as directed before administration to patients as an
intravenous. Infusion.
- You should not stop your therapy on your own for any reason.
- Never change your dosing schedule without talking to your doctor. It
is important that you use your medication exactly as directed.
- Your health care provider may tell you to stop your infusion if you
have a mechanical problem (such as a blockage in the tubing, needle, or
catheter); if you have to stop an infusion, call your health care
provider immediately so your therapy can continue.
Safety tips
- Your doctor should know if you are allergic to dobutamine or any
other drugs.
- Your doctor and pharmacist should be aware about what all medicines
you are taking.
- You should tell your doctor if you ever had heart valve disease or
high blood pressure.
- You should tell your doctor if you are pregnant, plan to become
pregnant, or are breast-feeding.
- If you become pregnant while taking dobutamine, call your doctor
immediately.
Common side effects
If you experience any of the following symptoms, call your health care
provider immediately:
- skin rash
- upset stomach
- fever
- irregular heartbeat
- vomiting
- tingling sensations
- increases in blood pressure and heart rate
- chest pain
- shortness of breath
- swelling of the lower legs and ankles
- increasing fatigue
- lightheadedness, dizziness, or faintness
- leg cramps
- headaches
Disclaimer:The above information is for general understanding of
the visitor. Please consult a registered medical practitioner before taking
the aforesaid medicine.
Injection
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