Celecoxib is an NSAID or
nonsteroidal anti-inflammatory drug used for treating arthritis, pain,
menstrual cramps, and colonic polyps. It has COX-2 selectivity. chemically,
it is a diaryl substituted pyrazole.
Brand Name: Celebrex
Iupac Name:
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Working
The drug acts by blocking the enzyme that makes prostaglandins
(cyclooxygenase 2), resulting in lower concentrations of prostaglandins.
This, in turn reduces the inflammation and its accompanying pain, fever,
swelling and tenderness.
The drug is different from other NSAID in the sense, that it causes less
inflammation and ulceration of the stomach and intestine and also does not
interfere with the clotting of blood.
Dosage
Osteoarthritis: 200mg per day administered as a single dose or as
100 mg twice per day.
Rheumatoid arthritis: 100-200 mg twice per day.
Contra- Indications: Hypersensitivity. It should not be given to
patients who have experienced allergic type reactions to Sulfonamides/
aspirin or other NSAIDs.
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Allergic reactions
- Gastrointestinal problems
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
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