Celecoxib is an NSAID or
nonsteroidal anti-inflammatory drug used for treating arthritis,
pain, menstrual cramps, and colonic polyps. It has COX-2
selectivity. chemically, it is a diaryl substituted pyrazole.
Brand Name: Celebrex
Iupac Name:
4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Working
The drug acts by blocking the enzyme that makes prostaglandins
(cyclooxygenase 2), resulting in lower concentrations of
prostaglandins. This, in turn reduces the inflammation and its
accompanying pain, fever, swelling and tenderness.
The drug is different from other NSAID in the sense, that it causes
less inflammation and ulceration of the stomach and intestine and
also does not interfere with the clotting of blood.
Dosage
Osteoarthritis: 200mg per day administered as a single dose
or as 100 mg twice per day.
Rheumatoid arthritis: 100-200 mg twice per day.
Contra- Indications: Hypersensitivity. It should not be
given to patients who have experienced allergic type reactions to
Sulfonamides/ aspirin or other NSAIDs.
Side Effects
The drug has certain side effects, that can affect individuals in
different ways. The following are some of the side effects, that are
often associated with the drug:
- Allergic reactions
- Gastrointestinal problems
Disclaimer: The above information is for general
understanding of the visitor. Please consult a registered medical
practitioner before taking the aforesaid medicine.
