Amoxycillin is a semi-synthetic
penicillin, an analogue of ampicillin, with a broad range of bactericidal
activity against many gram-positive and gram-negative micro-organisms. It is
stable in presence of gastric acid and may be given without regard to meals.
It acts through inhibition of biosynthesis of cell wall mucopeptide.
Amoxycillin is considered a good choice for treating acute sinusitis, acute
otitis media, and of acute exacerbations of chronic bronchitis. The drug is
superior to ordinary penicillin in these cases.
Brand Name: Amoxil, Penamox, Moxlin
Iupac Name: 7-[2-amino-2-(4-hydroxyphenyl)
-acetyl]amino-3,3-dimethyl-6-oxo 2-thia-5-azabicyclo[3.2.0]heptane
-4-carboxylic acid
Working
The drug works by inhibiting bacterial cell walls synthesis. It also slows
down or inhibits cross-linkage between the linear peptidoglycan polymer
chains that constitute a major component of the cell wall of Gram-positive
bacteria.
The drug, in its trihydrate form is available as tablets, capsules, or
syrup for oral use, and as sodium salt for being intravenously
administration
Dosage
Adult: 250mg to 1 gm thrice daily
Children : 20 mg/kg body weight in 3 divided doses
Contra- Indications
Individuals with a history of an allergic reaction to penicillin. Pregnancy
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
There is no known problem with use by elderly people. It can be safely
used by lactating mothers.
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
Injection
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Tablets