Allopurinol is a drug administered
orally or intravenously responsible for treating chronic gout arthritis. Its
major metabolite alloxanthine is long acting and non competitive
inhibitor-primarily responsible for uric acid synthesis inhibition.
It is also used for treating secondary hyperuricaemia, due to cancer
chemotherapy, ridiation & thiazides or drugs, prevention of uric acid
nephropathy.
The drug is available in tablet form and each (white) one contains 100 mg
allopurinol and other inactive ingredients including lactose, magnesium
stearate, potato starch, and povidone. Each peach colored tablet contains
300 mg allopurinol and other inactive ingredients including corn starch, FD&C
Yellow No. 6 Lake, lactose, magnesium stearate, and povidone.
Brand Name: Progout, Zyloprim, Allohexal, Zyloric
Iupac Name: 3,5,7,8-tetrazabicyclo[4.3.0] nona-3,5,9-trien-2-one
Working
This drug acts by inhibiting uric acid production in the body. It will
however not relieve a gout attack that has already started and does not cure
gout, but helps prevent gout attacks. The drug works only after regularly
use for a few months.
The drug is widely used for preventing or treating other medical problems
that may occur if too much uric acid is present in the body. eg: certain
kidney problems or kidney stones.
Dosage
Initially 100-200 mg daily . Maintain 200-600 mg daily
Contra- Indications: Children, acute gout
Side Effects
The drug has certain side effects, that can affect individuals in different
ways. The following are some of the side effects, that are often associated
with the drug:
- Rashes
- Fever
- Malaise
- Headache
- Nausea
- Gastric irritation
- Liver damage
Pregnant women should not use the drug, while lactating mothers can use
the drug with caution and under the guidance of a medical practitioner. In
case of elderly people, reduced may be necessary.
Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.
Receive QUOTES from Suppliers for FREE