Allopurinol is a drug administered orally or intravenously and is used for
treating chronic gout arthritis. Its major metabolite alloxanthine is long
acting and non competitive inhibitor-primarily responsible for uric acid
synthesis inhibition. The medicine works by reducing the amount of uric acid
produced by the body, which can cause gout and kidney problems. It is
populary known as Zyloric.
Brand Name
Progout, Zyloprim, Allohexal, Zyloric, Milurit, Alloril,
Zyrik 300
Uses of Allopurinol
- The main use of allopurinal is to remove excess uric acid in blood
plasma and its complications. This is medically referred as
hyperuricemia.
- It is also used for treating secondary hyperuricaemia, due to cancer
chemotherapy, radiation. In other words, it can decrease levels of uric
acid in people having cancer treatment.
- The medicine can be used to treat gout or kidney stones.
- The allopurinal medicine can be used in patients with poor kidney
function.
- Other treatments in which allopurinol is recommended ischemic
reperfusion injury, kidney stones with a uric acid component and
protozoal infections.
How Does Zyloprim Allopurinol Works?
This drug acts by inhibiting
uric acid production in the body. It will however not relieve a gout attack
that has already started and does not cure gout, but helps prevent gout
attacks. The drug works only after regularly use for a few months. The drug
is widely used for preventing or treating other medical problems that may
occur if too much uric acid is present in the body. eg: certain kidney
problems or kidney stones.
Dosage of Allopurinol
Initially 100-200 mg daily . Maintain 200-600
mg daily. The drug is available in tablet form and each (white) one contains
100 mg allopurinol and other inactive ingredients including lactose,
magnesium stearate, potato starch, and povidone. Each peach colored tablet
contains 300 mg allopurinol and other inactive ingredients including corn
starch, FD&C Yellow No. 6 Lake, lactose, magnesium stearate, and
povidone. It is usually taken once or twice a day, preferably after a meal.
Contra- Indications
Children, acute gout
Side Effects of Allopurinol
The drug has certain side effects, that
can affect individuals in different ways. The following are some of the side
effects, that are often associated with the drug:
- Rashes
- Fever
- Malaise
- Headache
- Nausea
- Gastric irritation
- Liver damage
Pregnant women should not use the drug, while lactating mothers can use
the drug with caution and under the guidance of a medical practitioner. In
case of elderly people, reduced may be necessary.
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Disclaimer: The above information is for general understanding
of the visitor. Please consult a registered medical practitioner before
taking the aforesaid medicine.