Angiotensin-converting Enzyme Inhibitors (ACE inhibitors) belong to the
first class of anti hypertensive agents. ACE inhibitors are one of the most
important group of drugs that prevent early death resulting from heart
failure, hypertension, or heart attacks. Some hypertension patients do not
respond well to ACE inhibitors alone. In such cases, ACE inhibitors are used
in combination with other drugs.
Why are Ace Inhibitors Used?
ACE inhibitors are used for the
following:
- Treating heart failure
- Controlling blood pressure
- Preventing strokes
- Preventing kidney damage of patients with diabetes or hypertension
How do Ace Inhibitors Work?
They work by preventing a chemical in
the blood, Angiotensin I, from being converted into a substance that
increases salt and water retention in the body. Increased salt and water
retention lead to high blood pressure. ACE inhibitors lower the amount of
salt and water in your body, which also helps to lower your blood pressure.
They block an enzyme in the body that is responsible for causing the blood
vessels to narrow. ACE Inhibitors make the blood vessels relax, which allows
more oxygen-rich blood to reach the heart and lowers your blood pressure.
Groups of Ace Inhibitors
Depending on the molecular structure, ace
inhibitrs can be divided into the following groups:
- Sulfhydryl-containing agents
- Dicarboxylate-containing agents
- Phosphonate-containing agents
Popular Ace Inhibitor Drugs
On the basis of th above groups, the
popular ace inhibitors are:
- Captopril , the first ACE inhibitor (belonging to
Sulfhydryl-containing agents)
- Enalapril, Ramipril, Quinapril, Perindopril, Lisinopril, Benazepril
(belonging to Dicarboxylate-containing agents)
- Fosinopril (belonging to Phosphonate-containing agents)
Ace Inhibitor Drugs for Various Disease Condition
- Benazepril, Lisinopril and Enalapril: For high blood pressure
- Captopril and Enalapril: For heart failure
- Lisinopril: After a heart attack
- Ramipril: For diabetics
- Ramipril and Benazepril: For people with kidney disease
Brand Names of Ace Inhibitors in the United States
Accupril
(quinapril), Altace (ramipril), Aceon (perindopril), Lotensin (benazepril),
Capoten (captopril), Monopril (fosinopril), Prinivil (lisinopril), Mavik
(trandolapril), Univasc (moexipril), Prinzide (lisinopril with a diuretic),
Vasotec (enalaprilat, enalapril), Vaseretic (enalapril with a diuretic),
Zestoretic (lisinopril with a diuretic), Zestril (lisinopril)
Send Online Enquiry for wholesale
Purchase of Ace Inhibitors