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Angiotensin-converting Enzyme Inhibitors (ACE inhibitors) belong to the first class of anti hypertensive agents. ACE inhibitors are one of the most important group of drugs that prevent early death resulting from heart failure, hypertension, or heart attacks. Some hypertension patients do not respond well to ACE inhibitors alone. In such cases, ACE inhibitors are used in combination with other drugs.
ACE inhibitors are used for the following:
They work by preventing a chemical in the blood, Angiotensin I, from being converted into a substance that increases salt and water retention in the body. Increased salt and water retention lead to high blood pressure. ACE inhibitors lower the amount of salt and water in your body, which also helps to lower your blood pressure. They block an enzyme in the body that is responsible for causing the blood vessels to narrow. ACE Inhibitors make the blood vessels relax, which allows more oxygen-rich blood to reach the heart and lowers your blood pressure.
Depending on the molecular structure, ace inhibitrs can be divided into the following groups:
On the basis of th above groups, the popular ace inhibitors are:
Accupril (quinapril), Altace (ramipril), Aceon (perindopril), Lotensin (benazepril), Capoten (captopril), Monopril (fosinopril), Prinivil (lisinopril), Mavik (trandolapril), Univasc (moexipril), Prinzide (lisinopril with a diuretic), Vasotec (enalaprilat, enalapril), Vaseretic (enalapril with a diuretic), Zestoretic (lisinopril with a diuretic), Zestril (lisinopril)
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